Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor AJ, Couchet M, Ribicic S, Wabitsch M, Messias AC, Iuso A, Müller TD, Rydén M, Mejhert N, Krahmer N (2024)
A spatiotemporal proteomic map of human adipogenesis.
Nature metabolism, Issue 5, Vol. 6, 861-879
DOI: 10.1038/s42255-024-01025-8, PubMed: 38565923

Zanuttigh E, Derderian K, Güra MA, Geerlof A, Di Meo I, Cavestro C, Hempfling S, Ortiz-Collazos S, Mauthe M, Kmieć T, Cammarota E, Panzeri MC, Klopstock T, Sattler M, Winkelmann J, Messias AC, Iuso A (2023)
Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro.
Pharmaceutics, Issue 1, Vol. 15
DOI: 10.3390/pharmaceutics15010267, PubMed: 36678896

Chora AF, Pedroso D, Kyriakou E, Pejanovic N, Colaço H, Gozzelino R, Barros A, Willmann K, Velho T, Moita CF, Santos I, Pereira P, Carvalho S, Martins FB, Ferreira JA, de Almeida SF, Benes V, Anrather J, Weis S, Soares MP, Geerlof A, Neefjes J, Sattler M, Messias AC, Neves-Costa A, Moita LF (2022)
DNA damage independent inhibition of NF-κB transcription by anthracyclines.
eLife, Vol. 11
DOI: 10.7554/eLife.77443, PubMed: 36476511

Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C (2020)
The dynamics of linear polyubiquitin.
Science advances, Issue 42, Vol. 6
DOI: 10.1126/sciadv.abc3786, PubMed: 33055165

De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT (2020)
Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.
Neurochemistry international, Vol. 136, 104713
DOI: 10.1016/j.neuint.2020.104713, PubMed: 32151623

Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B (2020)
Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action.
Angewandte Chemie (International ed. in English), Issue 14, Vol. 59, 5771-5781
DOI: 10.1002/anie.201914559, PubMed: 31863711

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2019)
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.
Diabetes, Issue 3, Vol. 68, 676
DOI: 10.2337/db19-er03a, PubMed: 30635274

Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC (2018)
Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.
Journal of medicinal chemistry, Issue 24, Vol. 61, 11144-11157
DOI: 10.1021/acs.jmedchem.8b01224, PubMed: 30525586

Ostertag MS, Messias AC, Sattler M, Popowicz GM (2019)
The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure (London, England : 1993), Issue 2, Vol. 27, 327-334.e3
DOI: 10.1016/j.str.2018.10.005, PubMed: 30449689

Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT (2019)
Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
International journal of obesity (2005), Issue 6, Vol. 43, 1305-1318
DOI: 10.1038/s41366-018-0221-z, PubMed: 30283080

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT (2018)
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Diabetes, Issue 11, Vol. 67, 2456-2465
DOI: 10.2337/db18-0146, PubMed: 30158241

Iuso A, Wiersma M, Schüller HJ, Pode-Shakked B, Marek-Yagel D, Grigat M, Schwarzmayr T, Berutti R, Alhaddad B, Kanon B, Grzeschik NA, Okun JG, Perles Z, Salem Y, Barel O, Vardi A, Rubinshtein M, Tirosh T, Dubnov-Raz G, Messias AC, Terrile C, Barshack I, Volkov A, Avivi C, Eyal E, Mastantuono E, Kumbar M, Abudi S, Braunisch M, Strom TM, Meitinger T, Hoffmann GF, Prokisch H, Haack TB, Brundel BJJM, Haas D, Sibon OCM, Anikster Y (2018)
Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy.
American journal of human genetics, Issue 6, Vol. 102, 1018-1030
DOI: 10.1016/j.ajhg.2018.03.022, PubMed: 29754768

Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H (2016)
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
Scientific reports, Vol. 6, 22540
DOI: 10.1038/srep22540, PubMed: 26931153

Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H (2016)
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
PloS one, Issue 2, Vol. 11, e0149477
DOI: 10.1371/journal.pone.0149477, PubMed: 26901434

Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D (2016)
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
Scientific reports, Vol. 6, 18934
DOI: 10.1038/srep18934, PubMed: 26740240

Xu T, Brandmaier S, Messias AC, Herder C, Draisma HH, Demirkan A, Yu Z, Ried JS, Haller T, Heier M, Campillos M, Fobo G, Stark R, Holzapfel C, Adam J, Chi S, Rotter M, Panni T, Quante AS, He Y, Prehn C, Roemisch-Margl W, Kastenmüller G, Willemsen G, Pool R, Kasa K, van Dijk KW, Hankemeier T, Meisinger C, Thorand B, Ruepp A, Hrabé de Angelis M, Li Y, Wichmann HE, Stratmann B, Strauch K, Metspalu A, Gieger C, Suhre K, Adamski J, Illig T, Rathmann W, Roden M, Peters A, van Duijn CM, Boomsma DI, Meitinger T, Wang-Sattler R (2015)
Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.
Diabetes care, Issue 10, Vol. 38, 1858-67
DOI: 10.2337/dc15-0658, PubMed: 26251408

Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A (2015)
Structural Characterization of LRRK2 Inhibitors.
Journal of medicinal chemistry, Issue 9, Vol. 58, 3751-6
DOI: 10.1021/jm5018779, PubMed: 25897865

Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, Boeing H, Joost HG, de Angelis MH, Rathmann W, Suhre K, Prokisch H, Peters A, Meitinger T, Roden M, Wichmann HE, Pischon T, Adamski J, Illig T (2012)
Novel biomarkers for pre-diabetes identified by metabolomics.
Molecular systems biology, Vol. 8, 615
DOI: 10.1038/msb.2012.43, PubMed: 23010998

Messias AC, Harnisch C, Ostareck-Lederer A, Sattler M, Ostareck DH (2006)
The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation.
Journal of molecular biology, Issue 3, Vol. 361, 470-81
DOI: 10.1016/j.jmb.2006.06.025, PubMed: 16854432

Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids.
Structure (London, England : 1993), Issue 7, Vol. 13, 1055-67
DOI: 10.1016/j.str.2005.04.008, PubMed: 16004877

Messias AC, Sattler M (2004)
Structural basis of single-stranded RNA recognition.
Accounts of chemical research, Issue 5, Vol. 37, 279-87
DOI: 10.1021/ar030034m, PubMed: 15147168