Schmidt T, Wiesbeck M, Egert L, Truong TT, Danese A, Voshagen L, Imhof S, Iraci Borgia M, Deeksha, Neuner AM, Köferle A, Geerlof A, Santos Dias Mourão A, Stricker SH (2025)
Efficient DNA- and virus-free engineering of cellular transcriptomic states using dCas9 ribonucleoprotein (dRNP) complexes.
Nucleic acids research, Issue 6, Vol. 53
DOI: 10.1093/nar/gkaf235, PubMed: 40156858

Bohnacker S, Henkel FDR, Hartung F, Geerlof A, Riemer S, Prodjinotho UF, Salah EB, Mourão ASD, Bohn S, Teder T, Thomas D, Gurke R, Boeckel C, Ud-Dean M, König AC, Quaranta A, Alessandrini F, Lechner A, Spitzlberger B, Kabat AM, Pearce E, Haeggström JZ, Hauck SM, Wheelock CE, Jakobsson PJ, Sattler M, Voehringer D, Feige MJ, da Costa CP, Esser-von Bieren J (2024)
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis.
Science immunology, Issue 102, Vol. 9, eadl1467
DOI: 10.1126/sciimmunol.adl1467, PubMed: 39642243

Ito J, Nakamura T, Toyama T, Chen D, Berndt C, Poschmann G, Mourão ASD, Doll S, Suzuki M, Zhang W, Zheng J, Trümbach D, Yamada N, Ono K, Yazaki M, Kawai Y, Arisawa M, Ohsaki Y, Shirakawa H, Wahida A, Proneth B, Saito Y, Nakagawa K, Mishima E, Conrad M (2024)
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization.
Molecular cell, Issue 23, Vol. 84, 4629-4644.e9
DOI: 10.1016/j.molcel.2024.10.028, PubMed: 39547222

Siebenmorgen T, Menezes F, Benassou S, Merdivan E, Didi K, Mourão ASD, Kitel R, Liò P, Kesselheim S, Piraud M, Theis FJ, Sattler M, Popowicz GM (2024)
MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery.
Nature computational science, Issue 5, Vol. 4, 367-378
DOI: 10.1038/s43588-024-00627-2, PubMed: 38730184

Matsuda A, Plewka J, Rawski M, Mourão A, Zajko W, Siebenmorgen T, Kresik L, Lis K, Jones AN, Pachota M, Karim A, Hartman K, Nirwal S, Sonani R, Chykunova Y, Minia I, Mak P, Landthaler M, Nowotny M, Dubin G, Sattler M, Suder P, Popowicz GM, Pyrć K, Czarna A (2024)
Despite the odds: formation of the SARS-CoV-2 methylation complex.
Nucleic acids research, Issue 11, Vol. 52, 6441-6458
DOI: 10.1093/nar/gkae165, PubMed: 38499483

Nakamura T, Ito J, Mourão ASD, Wahida A, Nakagawa K, Mishima E, Conrad M (2024)
A tangible method to assess native ferroptosis suppressor activity.
Cell reports methods, Issue 3, Vol. 4, 100710
DOI: 10.1016/j.crmeth.2024.100710, PubMed: 38401540

Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M (2023)
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.
Nature structural & molecular biology, Issue 11, Vol. 30, 1806-1815
DOI: 10.1038/s41594-023-01136-y, PubMed: 37957306

Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M (2023)
DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Nature, Issue 7968, Vol. 619, E9-E18
DOI: 10.1038/s41586-023-06269-0, PubMed: 37407687

Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M (2023)
Phase separation of FSP1 promotes ferroptosis.
Nature, Issue 7969, Vol. 619, 371-377
DOI: 10.1038/s41586-023-06255-6, PubMed: 37380771

Petriman NA, Loureiro-López M, Taschner M, Zacharia NK, Georgieva MM, Boegholm N, Wang J, Mourão A, Russell RB, Andersen JS, Lorentzen E (2022)
Biochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B.
The EMBO journal, Issue 24, Vol. 41, e112440
DOI: 10.15252/embj.2022112440, PubMed: 36354106

Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M (2022)
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Nature, Issue 7924, Vol. 608, 778-783
DOI: 10.1038/s41586-022-05022-3, PubMed: 35922516

Jones AN, Mourão A, Czarna A, Matsuda A, Fino R, Pyrc K, Sattler M, Popowicz GM (2022)
Characterization of SARS-CoV-2 replication complex elongation and proofreading activity.
Scientific reports, Issue 1, Vol. 12, 9593
DOI: 10.1038/s41598-022-13380-1, PubMed: 35688849

Jones AN, Tikhaia E, Mourão A, Sattler M (2022)
Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1.
Nucleic acids research, Issue 4, Vol. 50, 2350-2362
DOI: 10.1093/nar/gkac080, PubMed: 35166835

Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K (2022)
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Cell chemical biology, Issue 5, Vol. 29, 774-784.e8
DOI: 10.1016/j.chembiol.2021.11.006, PubMed: 35021060

Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S (2022)
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses.
Circulation research, Issue 1, Vol. 130, 67-79
DOI: 10.1161/CIRCRESAHA.121.320029, PubMed: 34789007

Zhang X, Schuhmachers P, Mourão A, Giansanti P, Murer A, Thumann S, Kuklik-Roos C, Beer S, Hauck SM, Hammerschmidt W, Küppers R, Kuster B, Raab M, Strebhardt K, Sattler M, Münz C, Kempkes B (2021)
PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice.
EMBO reports, Issue 12, Vol. 22, e53007
DOI: 10.15252/embr.202153007, PubMed: 34605140

Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S (2021)
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Nature communications, Issue 1, Vol. 12, 2999
DOI: 10.1038/s41467-021-22579-1, PubMed: 34016966

Zorro Shahidian L, Haas M, Le Gras S, Nitsch S, Mourão A, Geerlof A, Margueron R, Michaelis J, Daujat S, Schneider R (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.
EMBO reports, Issue 3, Vol. 22, e51009
DOI: 10.15252/embr.202051009, PubMed: 33512761

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020)
Autophagy unleashes noncanonical microRNA functions.
Autophagy, Issue 12, Vol. 16, 2294-2296
DOI: 10.1080/15548627.2020.1830523, PubMed: 33054575

Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020)
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
Science translational medicine, Issue 546, Vol. 12
DOI: 10.1126/scitranslmed.aaz2294, PubMed: 32493793

de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J (2020)
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.
Science translational medicine, Issue 540, Vol. 12
DOI: 10.1126/scitranslmed.aay0605, PubMed: 32321863

Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M (2019)
FSP1 is a glutathione-independent ferroptosis suppressor.
Nature, Issue 7784, Vol. 575, 693-698
DOI: 10.1038/s41586-019-1707-0, PubMed: 31634899

Taschner M, Lorentzen A, Mourão A, Collins T, Freke GM, Moulding D, Basquin J, Jenkins D, Lorentzen E (2018)
Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.
eLife, Vol. 7
DOI: 10.7554/eLife.33067, PubMed: 29658880

Taschner M, Mourão A, Awasthi M, Basquin J, Lorentzen E (2017)
Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.
The Journal of biological chemistry, Issue 18, Vol. 292, 7462-7473
DOI: 10.1074/jbc.M117.780155, PubMed: 28298440

Mourão A, Bonnal S, Soni K, Warner L, Bordonné R, Valcárcel J, Sattler M (2016)
Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation.
eLife, Vol. 5
DOI: 10.7554/eLife.14707, PubMed: 27894420

Mourão A, Christensen ST, Lorentzen E (2016)
Corrigendum to "The intraflagellar transport machinery in ciliary signaling" [Curr Opin Struct Biol 2016, 41:98-108].
Current opinion in structural biology, Vol. 41, 255
DOI: 10.1016/j.sbi.2016.07.018, PubMed: 27546002

Mourão A, Christensen ST, Lorentzen E (2016)
The intraflagellar transport machinery in ciliary signaling.
Current opinion in structural biology, Vol. 41, 98-108
DOI: 10.1016/j.sbi.2016.06.009, PubMed: 27393972

Taschner M, Weber K, Mourão A, Vetter M, Awasthi M, Stiegler M, Bhogaraju S, Lorentzen E (2016)
Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex.
The EMBO journal, Issue 7, Vol. 35, 773-90
DOI: 10.15252/embj.201593164, PubMed: 26912722

Mourão A, Nager AR, Nachury MV, Lorentzen E (2014)
Structural basis for membrane targeting of the BBSome by ARL6.
Nature structural & molecular biology, Issue 12, Vol. 21, 1035-41
DOI: 10.1038/nsmb.2920, PubMed: 25402481

Vojnic E, Mourão A, Seizl M, Simon B, Wenzeck L, Larivière L, Baumli S, Baumgart K, Meisterernst M, Sattler M, Cramer P (2011)
Structure and VP16 binding of the Mediator Med25 activator interaction domain.
Nature structural & molecular biology, Issue 4, Vol. 18, 404-9
DOI: 10.1038/nsmb.1997, PubMed: 21378965

Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M (2010)
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.
RNA (New York, N.Y.), Issue 6, Vol. 16, 1205-16
DOI: 10.1261/rna.2009910, PubMed: 20430857

Clerici M, Mourão A, Gutsche I, Gehring NH, Hentze MW, Kulozik A, Kadlec J, Sattler M, Cusack S (2009)
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
The EMBO journal, Issue 15, Vol. 28, 2293-306
DOI: 10.1038/emboj.2009.175, PubMed: 19556969

Friberg A, Corsini L, Mourão A, Sattler M (2009)
Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN.
Journal of molecular biology, Issue 4, Vol. 387, 921-34
DOI: 10.1016/j.jmb.2009.02.018, PubMed: 19232356